This report re-examines the role that e-cigarettes can play in preventing death, disability and inequalities resulting from tobacco use.

To examine the safety, tolerability, and effectiveness of using electronic cigarettes (ECs) to help tobacco smokers achieve long-term abstinence from smoking compared with non-nicotine ECs, other smoking cessation treatments, and no treatment.

For individuals who are unsuccessful in quitting smoking, a strategy based on tobacco harm management with a complete switch to smokeless products may be a less hazardous alternative to continued smoking.

An analysis of the need to incorporate non-combustible nicotine products into a model for reducing risks and harms related to tobacco use.

A monograph that addresses different aspects of the history, results and challenges of harm reduction in the continent where this approach was born.